Certain regions of the brain are more predisposed to further damage, especially after an infection or injury sensitizes said region to a secondary hit, often referred to in the literature as “hit and run effect”, which SARS-CoV-2 is a master on. As we covered recently, close to 25% of Long Covid patients have Central Nervous System manifestations, and sequelae, so addressing such changes is often a way to treat the condition. In many cases of brain fog after a SARS-CoV-2 infection, the pre-frontal cortex is the one that takes “the brunt of the damage”, and per the paper itself, this region is vulnerable because it used different receptors to function (NMDA receptors), and the way it deals with the flow of calcium and potassium can weaken the connectivity, especially during stress. (View Highlight)
I am fairly “anti-drug” and would prefer Long Covid patients to attempt other interventions before going on the drug route, but if you have tried a few combinations of supplements, consistently for a few months and saw no improvement, you should talk to your doctor on testing Guanfacine. I am fairly confident that 90% of the time the “stack” I often suggest to people will improve people’s health dramatically. (View Highlight)