The Serious Lack of Studies on the “Safety” of the Childhood Immunization Schedule
The Serious Lack of Studies on the “Safety” of the Childhood Immunization Schedule

The Serious Lack of Studies on the “Safety” of the Childhood Immunization Schedule

The above limitation of a recent Pfizer vaccine “safety” study for 5-11 year olds admitted that the safety of this vaccine, when used along with other vaccines, was not addressed (View Highlight)

In 1962, if children received any vaccines at all, at most, they encountered three different vaccines (5 doses total): for polio, smallpox, and DTP. Over (View Highlight)

By 1983, kids received at least 24 doses, and by 2018, this had more than tripled up to 76 doses (View Highlight)

Previous reports had found a casual relationship between vaccines and different adverse events. We can find some very telling admissions from this report regarding the damages and risks that vaccines carry: (View Highlight)

Vaccines can and do carry risks for complications that can be greater for some individuals than others and may lead to chronic brain and immune system damage or death (View Highlight)

What they ultimately found when reviewing the literature in 2013 was that there was not enough evidence to determine whether the childhood immunization schedule was or was not associated with the numerous adverse events and outcomes seen in children today such as: (View Highlight)

This first paper discusses the lack of studies comparing the safety of vaccine scheduling. It admits that this is a new area of research, meaning that the vaccine schedule, up to that time, had not been properly investigated for safety (View Highlight)

Some vaccines have been shown to cause an acute adverse event within a few weeks after vaccination. Examples include intussusception 3 to 7 days after vaccination with rotavirus vaccine (RotaShield (View Highlight)

febrile seizure 7 to 10 days after vaccination with MMR and the measles, mumps, rubella, and varicella (MMRV) vaccine (View Highlight)

It is plausible that two vaccines, if given separately from each other, do not increase the risk of adverse events, but if they are given on the same day, there is a vaccine-vaccine interaction effect (View Highlight)

For example, in a study of DTP and the measles vaccine in a low-income African country, Aaby et al (2004) hypothesized that “DTP as the last vaccine received may be associated with slightly increased mortality.” Veirum et al. (2005) suggested that “it might be examined whether provision of BCG [bacille Calmette-Guérin] or measles vaccine shortly after the last dose of DTP could secure specific protection and prevent the negative immune stimulation associated with having received DTP (View Highlight)

At the other extreme, it would be unethical to do a randomized trial where children in one arm are completely unvaccinated, since the scientist will then knowingly put some of the children at increased risk for vaccine-preventable diseases, some of which may result in death.” (View Highlight)

No study had ever compared unvaccinated against the vaccinated in order to contrast health outcomes. The research conducted was never of the mindset of looking at the vaccine schedules, and there was considerable uncertainty as to whether all health outcomes and safety concerns had been addressed: (View Highlight)

The committee’s review confirmed that research on immunization safety has mostly developed around studies examining potential associations between individual vaccines and single outcomes. Few studies have attempted more global assessments of entire sequence of immunizations or variations in the overall immunization schedule and categories of health outcomes (View Highlight)

None has compared entirely unimmunized populations with those fully immunized for the health outcomes of concern to stakeholders. (View Highlight)

Thus, the CDC reiterated what the IOM said and presented its own take on the guidelines on how to possibly study the vaccine schedule instead of actually doing studies on the vaccine schedule (View Highlight)

They highlight that any study would be considered unethical if it involved unvaccinated children as this would “needlessly endanger children’s lives.” (View Highlight)

Children who were undervaccinated because of parental choice had lower rates of outpatient visits and emergency department encounters (View Highlight)

Undervaccinated children appear to have different health care utilization patterns compared with age-appropriately vaccinated children” (View Highlight)

Regarding vaccines recommended for children and adolescents (KQ2), we found either no new evidence of increased risk for key adverse events with varied SoE or insufficient evidence, (View Highlight)

We acknowledge that studies of other widely used vaccines could be useful but were required to limit the scope to a focus on the United States. We also excluded non-English language studies. Although we were considering only vaccines approved for use in the United States, it is possible relevant epidemiological studies have been published in non-English journals.” (View Highlight)

Two studies that enrolled at-risk infants—one of DTaP in extremely low birth weight infants, and one of rotavirus vaccine in premature infants—reported an increased risk of certain adverse events such as evaluation for sepsis, need for respiratory support, and need for intubations after DTaP administration to extremely low birth weight infants, and bradycardia and apnea among premature infants receiving rotavirus vaccine (View Highlight)

The vaccinated were less likely than the unvaccinated to have been diagnosed with chickenpox and pertussis, but more likely to have been diagnosed with pneumonia, otitis media, allergies and NDD (View Highlight)

Remarkably, zero of the 561 unvaccinated patients in the study had attention deficit hyperactivity disorder (ADHD) compared to 5.3% of the (partially and fully) vaccinated (View Highlight)

Our results give agency to calls for research conducted by individuals who are independent of any funding sources related to the vaccine industry. While the low rates of developmental disorders prevented sufficiently powered hypothesis testing, it is notable that the overall rate of autism spectrum disorder (0.361%) in the cohort is one-fifth that of the US national rate (1.851%). The practice-wide rate of ADHD (View Highlight)

A few of the existing studies have shown that there are cases in which the risk of adverse events can depend on the vaccination schedule used (View Highlight)

in a study of DTP and the measles vaccine in a low-income African country, Aaby et al. (2004) hypothesized that “DTP as the last vaccine received may be associated with slightly increased mortality.” (View Highlight)

It is conceivable that the total number of vaccines given or the cumulative amount of immune-stimulating content, immunogenic adjuvants, or preservatives in all vaccines received can cause adverse events (View Highlight)

Many more vaccines are recommended before 24 months of age than at any other age and parents are (View Highlight)

The prior 2014 report noted signals for rare adverse events—such as anaphylaxis, idiopathic thrombocytopenic purpura, and febrile seizures—with some childhood vaccines (View Highlight)

Some studies did find an increased risk of febrile seizures with MMR-V, and healthcare providers may wish to ensure that families are aware of this risk when balancing it against the benefit of giving one injection instead of two injections (View Highlight)

Vaccination, but not preterm birth, remained associated with NDD, while the interaction of preterm birth and vaccination was associated with a 6.6-fold increased odds of NDD (95% CI: 2.8, 15.5) (View Highlight)

A 2020 study found vaccination before 1 year of age was associated with increased odds of developmental delays (OR = 2.18, 95% CI 1.47–3.24), asthma (OR = 4.49, 95% CI 2.04–9.88) and ear infections (OR = 2.13, 95% CI 1.63–2.78) (View Highlight)

The researchers could detect no widespread negative health effects in the unvaccinated other than the rare but significant vaccine-targeted diagnosis (View Highlight)